| Identification | Back Directory | [Name]
L-Arginine, L-α-glutamyl-L-leucyl-L-glutaminyl-L-leucyl-L-leucyl-L-methionyl-L-glutaminyl-L-seryl-L-threonyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-asparaginyl- | [CAS]
406477-46-1 | [Synonyms]
L-Arginine, L-α-glutamyl-L-leucyl-L-glutaminyl-L-leucyl-L-leucyl-L-methionyl-L-glutaminyl-L-seryl-L-threonyl-L-prolyl-L-prolyl-L-threonyl-L-asparaginyl-L-asparaginyl- | [Molecular Formula]
C73H124N22O25S | [MOL File]
406477-46-1.mol | [Molecular Weight]
1741.97 |
| Chemical Properties | Back Directory | [density ]
1.52±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
3.27±0.10(predicted) | [Sequence]
Glu-Leu-Gln-Leu-Leu-Met-Gln-Ser-Thr-Pro-Pro-Thr-Asn-Asn-Arg |
| Hazard Information | Back Directory | [Uses]
Fusion glycoprotein 92-106 is a polypeptide from fusion protein of respiratory syncytial virus (RSV). Fusion glycoprotein 92-106 acts as MHC class I-restricted CTL epitope, that all 15 amino acids are required for efficient recognition by cytotoxic T lymphocyte (CTL)[1]. | [in vivo]
Fusion glycoprotein 92-106 (100 μg, sc, twice a week for 3 weeks) induces a protective immune responses against RSV infection in BALB/c mice model[1]. | Animal Model: | RSV infected BASLB/c mice model[1] | | Dosage: | 100 μg | | Administration: | sc, twice a week | | Result: | Promoted the differentiation of CD8+, MHC class I-restricted CTL.
Decreased the virus titre after RSV infection. |
| [References]
[1] Jiang S, et al., Virus-specific CTL responses induced by an H-2K(d)-restricted, motif-negative 15-mer peptide from the fusion protein of respiratory syncytial virus. J Gen Virol. 2002 Feb;83(Pt 2):429-438. DOI:10.1099/0022-1317-83-2-429 |
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