| Identification | Back Directory | [Name]
1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE | [CAS]
406482-22-2 | [Synonyms]
4-Bromo-2,3-difluoroanisole
4-Bromo-2,3-difluoroanisole98%
4-Bromo-2,3-difluoroanisole 98%
1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE
1-Bromo-2,3-difluoro-4-methoxybenzene
Benzene, 1-bromo-2,3-difluoro-4-methoxy-
1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE ISO 9001：2015 REACH | [EINECS(EC#)]
-0 | [Molecular Formula]
C7H5BrF2O | [MDL Number]
MFCD07368017 | [MOL File]
406482-22-2.mol | [Molecular Weight]
223.01 |
| Chemical Properties | Back Directory | [Melting point ]
56-58° | [Boiling point ]
203.2±35.0 °C(Predicted) | [density ]
1.615 | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure: iodomethane (1.56 mL, 25.1 mmol, 1.5 eq.) was slowly added dropwise to a suspension of 2,3-difluoro-4-bromophenol (3.5 g, 16.7 mmol) and potassium carbonate (2.77 g, 20.0 mmol, 1.2 eq.) in N,N-dimethylformamide (30 mL). The reaction mixture was stirred at room temperature for 3 days. After completion of the reaction, the insoluble precipitate was removed by filtration. The filtrate was concentrated to dryness under reduced pressure. Dichloromethane and water were added to the residue and the product was extracted with dichloromethane. The organic phases were combined, dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to afford 4-bromo-2,3-difluoroanisole as a white crystalline solid (3.8 g, quantitative yield). | [References]
[1] Patent: WO2012/175991, 2012, A1. Location in patent: Page/Page column 78 |
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