| Identification | Back Directory | [Name]
Sodium octadecyl fumarate | [CAS]
4070-80-8 | [Synonyms]
Pruv
4070-80-8
Sod. Stearyl fumarate
SodiuM Srearyl FuMarate
Sodium stearyi fumarate
SODIUM STEARYL FUMARATE
SODIUMSTEARYLFUMARATE,NF
SODIUMSTEARYLFUMARATE,FCC
sodium octadecyl fumarate
Sodium stearyl 2-fumarate
SODIUMMONO-STEARYLFUMARATE
Sodium 2-octadecylfumarate
Monosodium stearyl fumarate
Sodium Stearyl Fumarate (200 mg)
SodiuM Stearyl FuMarate, 98.0%(T)
Sodium Stearyl Fumarate (Excipient)
Fumaric acid 1-stearyl 4-sodium salt
Fumaric acid 1-octadecyl 4-sodium salt
SodiumStearylFumarate(Excipient)OpenPartDmf
sodiuM (E)-4-(octadecyloxy)-4-oxobut-2-enoate
fumaric acid, monooctadecyl ester, sodium salt
(E)-2-Butenedioic acid 1-octadecyl 4-sodium salt
(E)-2-Butenedioic acid monooctadecyl ester sodium salt
2-Butenedioic acid (2E)-, monooctadecyl ester, sodium salt
Fumaric Acid Stearyl Ester Sodium Salt
Sodium Octadecyl Fumarate
Fumaric Acid Octadecyl Ester Sodium Salt | [EINECS(EC#)]
223-781-1 | [Molecular Formula]
C22H39NaO4 | [MDL Number]
MFCD00236640 | [MOL File]
4070-80-8.mol | [Molecular Weight]
390.53 |
| Chemical Properties | Back Directory | [Melting point ]
>196°C (dec.) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Practically insoluble in water, slightly soluble in methanol, practically insoluble in acetone and in anhydrous ethanol. | [form ]
neat | [color ]
White to Off-White | [InChIKey]
GKCVIRALYIXVLE-RZLHGTIFSA-M | [LogP]
8.789 (est) | [Uses]
Sodium Stearyl Fumarate is a dough conditioner and conditioning agent that is a white powder practically insoluble in water. It is used as a dough conditioner in yeast-raised baked goods. It is used as a conditioning agent in dehydrated potatoes. It also functions as a maturing and bleaching agent. |
| Hazard Information | Back Directory | [Usage]
Binder | [Usage]
cationic transfection agent, bile acid sequestrant, vaccine adjuvant, protein stabilizer | [Chemical Properties]
Sodium stearyl fumarate is a fine, white powder with agglomerates
of flat, circular-shaped particles. | [Chemical Properties]
White or off-white crystalline powder | [Production Methods]
Stearyl alcohol is reacted with maleic anhydride. The product of this
reaction then undergoes an isomerization step followed by salt
formation to produce sodium stearyl fumarate. | [Pharmaceutical Applications]
Sodium stearyl fumarate is used as a lubricant in capsule and tablet
formulations at 0.5–2.0% w/w concentration. It is also used in
certain food applications. | [Safety]
Sodium stearyl fumarate is used in oral pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritant
material.
Metabolic studies of sodium stearyl fumarate in the rat and dog
indicated that approximately 80% was absorbed and 35% was
rapidly metabolized. The fraction absorbed was hydrolyzed to stearyl alcohol and fumaric acid, with the stearyl alcohol further
oxidized to stearic acid. In the dog, sodium stearyl fumarate that
was not absorbed was excreted unchanged in the feces within 24
hours.
Stearyl alcohol and stearic acid are naturally occurring
constituents in various food products, while fumaric acid is a
normal constituent of body tissue. Stearates and stearyl citrate have
been reviewed by the WHO and an acceptable daily intake for
stearyl citrate has been set at up to 50 mg/kg body-weight. The
establishment of an acceptable daily intake for stearates and
fumaric acid was thought unnecessary.
Disodium fumarate has been reported to have a toxicity not
greatly exceeding that of sodium chloride. | [storage]
At ambient temperature, sodium stearyl fumarate is stable for up to
3 years when stored in amber glass bottles with polyethylene screw
caps.
The bulk material should be stored in a well-closed container in a
cool, dry place. | [Incompatibilities]
Sodium stearyl fumarate is reported to be incompatible with
chlorhexidine acetate. | [Regulatory Status]
GRAS listed. Permitted by the FDA for direct addition to food for
human consumption as a conditioning or stabilizing agent in
various bakery products, flour-thickened foods, dehydrated potatoes,
and processed cereals up to 0.2–1.0% by weight of the food.
Included in nonparenteral medicines licensed in the UK. Included in
the FDA Inactive Ingredients Database (oral capsules and tablets).
Included in the Canadian List of Acceptable Non-medicinal
Ingredients. |
| Questions and Answers (Q&A) | Back Directory | [Description]
Sodium Stearyl Fumarate (SSF) is used as a lubricant in tableting to reduce the friction between the tablet and the die wall and to prevent adhesion of the material to punches or the die wall in the pharmaceutical industries. It is used also as a lubricant in the manufacturing of capsules and other oral dosage forms. Sodium stearyl fumarate is also used in food production as a dough conditioner, a conditioning agent, and a stabilizing agent.
| [References]
[1] Arne W. Hölzer and John Sjögren, Evaluation of sodium stearyl fumarate as a tablet lubricant, International Journal of Pharmaceutics, 1979, vol. 2, 145-153
[2] Holger Zorn and Peter Czermak, Biotechnology of Food and Feed Additives, 2014
[3] https://www.fda.gov
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