| Identification | Back Directory | [Name]
6-Chloropyridine-3-sulfonamide | [CAS]
40741-46-6 | [Synonyms]
6-CHLOROPYRIDINE-3-SULFONAMIDE
6-Chloro-3-pyridinesulfonaMide
3-Pyridinesulfonamide, 6-chloro-
6-Chloro-pyridine-3-sulfonic acid aMide
3-Pyridinesulfonamide,6-chloro-(7CI,9CI)
6-Chloropyridine-3-sulfonamide ISO 9001：2015 REACH | [EINECS(EC#)]
145-896-5 | [Molecular Formula]
C5H5ClN2O2S | [MDL Number]
MFCD00661410 | [MOL File]
40741-46-6.mol | [Molecular Weight]
192.62 |
| Chemical Properties | Back Directory | [Melting point ]
158-159 °C(Solv: water (7732-18-5)) | [Boiling point ]
383.2±52.0 °C(Predicted) | [density ]
1.558±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
9.24±0.60(Predicted) |
| Hazard Information | Back Directory | [Uses]
6-Chloro-3-pyridinesulfonamide, is a heterocylic building block used for chemical synthesis. It can also be used for the synthesis of diuretics and carbonic anhydrase inhibitors. | [Synthesis]
The general procedure for the synthesis of 6-chloro-3-sulfapyridine from 2-chloropyridine-5-sulfonyl chloride was as follows: 6-chloropyridine-3-sulfonyl chloride (5.0 g, 0.024 mol) was dissolved in a 0.5 M ammonia dioxane solution (125 mL) at -50 °C. The reaction mixture was slowly warmed to room temperature and stirred continuously for 1 hour. After completion of the reaction, the mixture was filtered through diatomaceous earth and the filter cake was washed twice with dioxane. The filtrate was concentrated in vacuum to afford 6-chloropyridine-3-sulfonic acid amide as an off-white solid in a yield of 4.55 g (98% yield). The product was analyzed by liquid chromatography (LC) under the detection condition of UV215 nm; retention time (Rt) 1.05 min and 100% purity. Mass spectrometry (m/z) analytical result (ES+): 193/195. NMR hydrogen spectroscopy (400 MHz; d6-DMSO) data: δ 8.79 (1H, d), 8.21 (1H, dd), 7.75 (1H, d), 7.70 (2H, br s). | [References]
[1] Patent: WO2008/49605, 2008, A1. Location in patent: Page/Page column 15-16
[2] Patent: WO2008/138594, 2008, A1. Location in patent: Page/Page column 16
[3] Patent: WO2008/21389, 2008, A2. Location in patent: Page/Page column 253
[4] Patent: WO2007/44729, 2007, A2. Location in patent: Page/Page column 186
[5] Patent: WO2008/127594, 2008, A2. Location in patent: Page/Page column 376 |
|
|