| Identification | Back Directory | [Name]
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid | [CAS]
407587-33-1 | [Synonyms]
CaCCinh-A01
TMEM16 BLOCKER I
CaCC(inh)-A01, TMEM16 Blocker I.
CACCINH-A01; CACC(INH)-A01, TMEM16 BLOCKER I.
6-tert-butyl-2-(furan-2-carboxaMido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid
6-(1,1-Dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid
Benzo[b]thiophene-3-carboxylic acid, 6-(1,1-dimethylethyl)-2-[(2-furanylcarbonyl)amino]-4,5,6,7-tetrahydro- | [Molecular Formula]
C18H21NO4S | [MDL Number]
MFCD02919058 | [MOL File]
407587-33-1.mol | [Molecular Weight]
347.43 |
| Chemical Properties | Back Directory | [Boiling point ]
429.7±45.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble20mg/mL, clear | [form ]
powder | [pka]
4.49±0.40(Predicted) | [color ]
white to beige | [InChI]
1S/C18H21NO4S/c1-18(2,3)10-6-7-11-13(9-10)24-16(14(11)17(21)22)19-15(20)12-5-4-8-23-12/h4-5,8,10H,6-7,9H2,1-3H3,(H,19,20)(H,21,22) | [InChIKey]
ACLUEOBQFRYTQS-UHFFFAOYSA-N | [SMILES]
[s]1c2c(c(c1NC(=O)c3[o]ccc3)C(=O)O)CCC(C2)C(C)(C)C |
| Hazard Information | Back Directory | [Uses]
CaCC(inh)-A01 is a potent, selective class A inhibitor of calcium-activated chloride channels (CaCCs). | [Biochem/physiol Actions]
CaCCinh-A01 is a TMEM16A (transmembrane member 16A) inhibitor. It also blocks anoctamin-1 (ANO1) and decreases cell viability and represses cell migration. | [in vivo]
CaCCinh-A01 (vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion) significantly reduces infarction when compared with MCAO-saline treatment at 24 h or 72 h in middle cerebral artery occlusion model in mice[3]. | Animal Model: | Two-month-old male C57/BL6J mice[3] | | Dosage: | 5 mg/kg | | Administration: | Vein injection; 5 mg/kg; caudal vein injection within 15 min after the onset of reperfusion | | Result: | Attenuated brain infarct size, improved neurological outcomes and lowered BBB permeability after ischemic stroke in mice. |
| [storage]
Store at -20°C |
|
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Sigma-Aldrich
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