| Identification | Back Directory | [Name]
alpha-lipoic acid-NHS | [CAS]
40846-94-4 | [Synonyms]
lipoic acid-NHS
α-Lipoic acid-NHS
DL-α-Lipoic Acid-NHS
alpha-lipoic acid-NHS
N-Hydroxysuccinimidyl Lipoate
Thioctic acid N-hydroxysuccinimide ester
1,2-Dithiolane-3-pentanoic acid succinimidyl ester, 95%
2,5-Dioxopyrrolidin-1-yl 5-(1,2-Dithiolan-3-yl)pentanoate
5-(1,2-Dithiolan-3-yl)pentanic Acid 2,5-Dioxopyrrolidin-1-yl Ester
Thioctic acid (2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate) | [Molecular Formula]
C12H17NO4S2 | [MDL Number]
MFCD09028032 | [MOL File]
40846-94-4.mol | [Molecular Weight]
303.4 |
| Chemical Properties | Back Directory | [Melting point ]
95 °C | [Boiling point ]
437.1±28.0 °C(Predicted) | [density ]
1.36±0.1(20.0000℃) | [solubility ]
Soluble in DMSO, DMF, DCM | [form ]
powder to crystal | [color ]
White to Yellow to Orange |
| Hazard Information | Back Directory | [Description]
alpha-lipoic acid-NHS contains a lipoic acid group and a terminal NHS group. The NHS group can participate in reactions with primary amine groups to form amide bonds. | [Uses]
α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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