| Identification | Back Directory | [Name]
Methyl 2,6-dichloro-4-cyanobenzoate | [CAS]
409127-32-8 | [Synonyms]
2，6-dichloro-4-cyanobenzoic acid
Methyl 2,6-difluoro-4-Cyanobenzoate
Methyl 2,6-dichloro-4-cyanobenzoate
Benzoic acid, 2,6-dichloro-4-cyano-, methyl ester | [Molecular Formula]
C9H5Cl2NO2 | [MDL Number]
MFCD13194678 | [MOL File]
409127-32-8.mol | [Molecular Weight]
230.05 |
| Chemical Properties | Back Directory | [Boiling point ]
319.6±42.0 °C(Predicted) | [density ]
1.45 | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
Step a: Synthesis of methyl 2,6-dichloro-4-cyanobenzoate
Methyl 4-carbamoyl-2,6-dichlorobenzoate (100 mg, 0.4 mmol) was dissolved in pyridine (2 mL) and trifluoroacetic anhydride (0.11 mL, 0.8 mmol) was added slowly and dropwise at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the mixture was poured into pre-cooled ice water, the precipitated solid was filtered, washed thoroughly with cold water and dried to afford methyl 2,6-dichloro-4-cyanobenzoate (55 mg, 88% yield) as an off-white solid. | [References]
[1] Patent: WO2012/160464, 2012, A1. Location in patent: Page/Page column 77-78
[2] Patent: US2014/155398, 2014, A1. Location in patent: Paragraph 0468
[3] Patent: US2010/317643, 2010, A1. Location in patent: Page/Page column 101
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 11, p. 4521 - 4536 |
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