| Identification | Back Directory | [Name]
2',3'-DIDEOXY-3'-FLUOROURIDINE | [CAS]
41107-56-6 | [Synonyms]
Fddurd
3'-FLUORO-2',3'-DIDEOXYURIDINE
2',3'-DIDEOXY-3'-FLUOROURIDINE
URIDINE, 2',3'-DIDEOXY-3'-FLUORO-
1-(2,3-DIDEOXY-3-FLUORO-BETA-D-RIBOFURANOSYL)URACIL
5-(2,4-dioxo-1,2,3,4-tetrahydropyrimidine)-3-fluoro-2-hydroxymethyltetrahydrofuran | [EINECS(EC#)]
415-360-8 | [Molecular Formula]
C9H11FN2O4 | [MDL Number]
MFCD00192015 | [MOL File]
41107-56-6.mol | [Molecular Weight]
230.19 |
| Chemical Properties | Back Directory | [Appearance]
Off-white solid | [Melting point ]
184-188 °C(lit.)
| [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Aqueous Base (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly), Water | [form ]
Solid | [pka]
9.39±0.10(Predicted) | [color ]
White to Off-White | [Optical Rotation]
[α]20/D +10.5°, c = 0.5 in 1 M NaOH | [BRN ]
6064366 | [InChI]
1S/C9H11FN2O4/c10-5-3-8(16-6(5)4-13)12-2-1-7(14)11-9(12)15/h1-2,5-6,8,13H,3-4H2,(H,11,14,15)/t5-,6+,8+/m0/s1 | [InChIKey]
BKIUEHLYJFLWPK-SHYZEUOFSA-N | [SMILES]
OC[C@H]1O[C@H](C[C@@H]1F)N2C=CC(=O)NC2=O |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white solid | [Uses]
2'',3''-Dideoxy-3''-fluorouridine is a reactant used in the synthesis of 5''-trityl nucleosides as inhibitors of Plasmodium falciparum dUTPase. | [Uses]
2′,3′-Dideoxy-3′-fluorouridine can be used as a starting material in the synthesis of:
- 3′-fluoro 2′,3′-dideoxynucleoside analogs for in vitro antiviral activity studies.
- 3′-fluoro deoxyuridine monophosphate analogs as potential anti parasites.
| [General Description]
2′,3′-Dideoxy-3′-fluorouridine (3′-fluoro-2′,3′-dideoxyuridine, FddUrd) is a fluorinated pyrimidine nucleoside analog of uridine. It has been studied extensively for its potential use as an antiviral agent against HIV. |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Warning | [Hazard statements ]
H341 | [Precautionary statements ]
P281 | [Hazard Codes ]
Xn | [Risk Statements ]
68 | [Safety Statements ]
22-36/37 | [WGK Germany ]
1
| [HS Code ]
29349990 | [Storage Class]
13 - Non Combustible Solids | [Hazard Classifications]
Muta. 2 |
|
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