| Identification | Back Directory | [Name]
5-chloro-2,3-diphenylpyrazine | [CAS]
41270-66-0 | [Synonyms]
Selexipag Impurity 31
2-Chloro-5,6-diphenylpyrazine
Pyrazine, 5-chloro-2,3-diphenyl-
chloro-2,3-diphenylpyrazine
(Selexipag Intermediate) | [EINECS(EC#)]
813-797-2 | [Molecular Formula]
C16H11ClN2 | [MDL Number]
MFCD00234892 | [MOL File]
41270-66-0.mol | [Molecular Weight]
266.725 |
| Chemical Properties | Back Directory | [Melting point ]
126-128℃ (methanol ) | [Boiling point ]
145°C/0.001mmHg(lit.) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C, sealed storage, away from moisture | [form ]
powder to crystal | [pka]
-2.16±0.10(Predicted) | [color ]
White to Orange to Green | [InChI]
InChI=1S/C16H11ClN2/c17-14-11-18-15(12-7-3-1-4-8-12)16(19-14)13-9-5-2-6-10-13/h1-11H | [InChIKey]
VUGNCPVAXWZTOL-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=CC=C2)=NC=C(Cl)N=C1C1=CC=CC=C1 | [CAS DataBase Reference]
41270-66-0 |
| Hazard Information | Back Directory | [Uses]
2-Chloro-5,6-diphenylpyrazine is a diphenylpyrazine derivative used in a study to determine a novel class of prostacyclin receptor agonists. | [Synthesis]
50 gm of 2-hydroxy-5,6-diphenylpyrazine obtained was treated with 250 ml of POCI3 and then heated the reaction mixture at 100-110 °C with stirring for 5-6 hrs. The reaction mixture was cooled to room temperature and poured in 1000 ml of ice water at 0-5 °C and maintained with stirring for 60 minutes. The solid obtained was filtered, washed with water and dried to obtain 41.3 gm of 5-chloro-2,3-diphenylpyrazine. Yield: 77.00 percent.
| [References]
[1] Journal of the American Chemical Society, 1952, vol. 74, p. 1580,1582
[2] Patent: WO2017/168401, 2017, A1. Location in patent: Page/Page column 12 |
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Jia Xing Isenchem Co.,Ltd
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