| Identification | Back Directory | [Name]
Hdm2 E3 Ligase Inhibitor | [CAS]
414905-09-2 | [Synonyms]
Hdm2 E3 Ligase Inhibitor
Propanamide, N-[4-(aminosulfonyl)phenyl]-3,3,3-trifluoro-2-(trifluoromethyl)- | [Molecular Formula]
C10H8F6N2O3S | [MDL Number]
MFCD09037538 | [MOL File]
414905-09-2.mol | [Molecular Weight]
350.24 |
| Hazard Information | Back Directory | [Uses]
Hdm2 E3 ligase inhibitor 1 (Compound 1) is a reversible inhibitor for Hdm2 (an E3 ubiquitin ligase)-mediated ubiquitination of the p53 protein with an IC50 of 12.7 μM. Hdm2 E3 ligase inhibitor 1 binds Hdm2, blocks Hdm2-catalyzed ubiquitin transfer from preligated Ub-Ubc4 to p53, inhibits p53 ubiquitination, stabilizes p53 protein in tumor cell and exhibits antitumor efficacy[1]. | [References]
[1] Lai Z, et al., Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14734-9. DOI:10.1073/pnas.212428599 |
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| Company Name: |
Alabiotech Inc.
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| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
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