| Identification | Back Directory | [Synonyms]
GS 389
HIGE-004
6,7-Dimethoxy-1-(4-methoxybenzyl)-1,2,3,4-tetrahydroisoquinoline
1,2,3,4-Tetrahydro-1-(4-methoxybenzyl)-6,7-dimethoxyisoquinoline
1,2,3,4-Tetrahydro-6,7-dimethoxy-1-(4-methoxybenzyl)isoquinoline
6,7-diMethoxy-1-(4-Methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-2-iuM chloride | [MDL Number]
MFCD00914751 |
| Hazard Information | Back Directory | [Description]
GS 389 is a novel tetrahydroisoquinoline analog. GS-389 significantly increased cGMP levels in the rat aorta and inhibited cGMP phosphodiesterase from the rabbit brain. It has vasorelaxant properties. | [Uses]
GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1]. | [References]
[1] Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334. DOI:10.1139/y94-049 |
|
| Company Name: |
BePharm Ltd
|
| Tel: |
400-685-9117 |
| Website: |
www.bepharm.com |
| Company Name: |
CHEMICAL LAND21
|
| Tel: |
82- 2 -783 - 8063 |
| Website: |
www.chemicalland21.com |
|