| Identification | Back Directory | [Name]
A2AR-agonist-1 | [CAS]
41552-95-8 | [Synonyms]
A2AR-agonist-1
Adenosine, N-[2-(1H-indol-3-yl)ethyl]- | [Molecular Formula]
C20H22N6O4 | [MDL Number]
MFCD01754449 | [MOL File]
41552-95-8.mol | [Molecular Weight]
410.43 |
| Chemical Properties | Back Directory | [Melting point ]
187.0-187.2 °C | [Boiling point ]
828.7±75.0 °C(Predicted) | [density ]
1.67±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mM | [form ]
A solid | [pka]
13.12±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
A2AR agonist-1 is an agonist of the adenosine A2A receptor and an inhibitor of equilibrative nucleoside transporter 1 (ENT1). A2AR agonist-1 also rescues motor performance and increases survival in a transgenic mouse model of Huntington’s disease. | [Uses]
A2AR-agonist-1 is a potent A2AR and ENT1 agonist with Ki of 4.39 and 3.47 for A2AR and ENT1.
IC50 value: 4.39 and 3.47 (Ki) [1]
Target: A2AR and ENT1
A2AR-agonist-1 is a novel dual-action compound, targeting the Adenosine A2A Receptor and Adenosine Transporter for Neuroprotection.[1] | [storage]
Store at -20°C | [References]
[1] Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-1400. DOI:10.1002/cmdc.201100126
[2] Lin Yun-Lian, et al. Dual-action compounds targeting adenosine A2A receptor and adenosine transporter for prevention and treatment of neurodegenerative diseases. From PCT Int. Appl. (2012), WO 2012064340 A1 20120518.
[3] Chen, Chih-Cheng, et al. Methods and compositions for treating pain. From PCT Int. Appl. (2013), WO 2013120078 A1 20130815. |
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