| Identification | Back Directory | [Name]
2(5H)-Furanone, 3-[(3aR,5aS,6R,7R,9aR,9bS)-dodecahydro-7-hydroxy-6-(hydroxymethyl)-3a,6,9a-trimethylnaphtho[2,1-b]furan-2-yl]- | [CAS]
4176-96-9 | [Synonyms]
2(5H)-Furanone, 3-[(3aR,5aS,6R,7R,9aR,9bS)-dodecahydro-7-hydroxy-6-(hydroxymethyl)-3a,6,9a-trimethylnaphtho[2,1-b]furan-2-yl]- | [Molecular Formula]
C20H30O5 | [MOL File]
4176-96-9.mol | [Molecular Weight]
350.45 |
| Chemical Properties | Back Directory | [Melting point ]
198-198.5 °C(Solv: ethyl acetate (141-78-6)) | [Boiling point ]
527.9±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [pka]
14.85±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice[1][2]. | [References]
[1] T Matsuda, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo). 1994 Jun;42(6):1216-25. DOI:10.1248/cpb.42.1216
[2] Zhe Song, et al. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice. Int Immunopharmacol. 2022 Apr;105:108539. DOI:10.1016/j.intimp.2022.108539 |
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