| Identification | Back Directory | [Name]
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one | [CAS]
41931-13-9 | [Synonyms]
LCS-1
LCS-1
(LCS1)
SOD1 Inhibitor, LCS-1
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one
4,5-dichloro-2-(3-methylphenyl)pyridazin-3-one
4,5-Dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone
SOD1 Inhibitor, LCS-1 - CAS 41931-13-9 - Calbiochem
3(2H)-Pyridazinone, 4,5-dichloro-2-(3-methylphenyl)-
4,5-dichloro-2-(3-Methylphenyl)-2,3-dihydropyridazin-3-one
4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one ISO 9001：2015 REACH | [Molecular Formula]
C11H8Cl2N2O | [MDL Number]
MFCD00814448 | [MOL File]
41931-13-9.mol | [Molecular Weight]
255.1 |
| Chemical Properties | Back Directory | [Melting point ]
117 °C | [Boiling point ]
339.6±52.0 °C(Predicted) | [density ]
1.39±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL (clear solutikon, warmed) | [form ]
White solid | [pka]
-3.29±0.60(Predicted) | [color ]
white to beige | [InChI]
1S/C11H8Cl2N2O/c1-7-3-2-4-8(5-7)15-11(16)10(13)9(12)6-14-15/h2-6H,1H3 | [InChIKey]
SYUPLLHVMCLXEM-UHFFFAOYSA-N | [SMILES]
O=C1C(Cl)=C(Cl)C=NN1C2=CC=CC(C)=C2 |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xi | [Risk Statements ]
25-36 | [Safety Statements ]
26-45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Eye Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
LCS 1 is an inhibitor of Superoxide Dismutase 1 (SOD1). | [Biochem/physiol Actions]
LCS-1 is an inhibitor of superoxide dismutase (SOD1). LCS-1 inhibits the proliferation of lung adendocarcinoma cell lines. | [in vivo]
LCS-1 (20 mg/kg; i.p. every other day for 14 days) inhibits MM growth and prolongs host survival in MM.1S-bearing mice[3]. | Animal Model: | 5-week-old female CB17 SCID mice (MM.1S tumors volume=100 mm3)[3] | | Dosage: | 20 mg/kg (diluted in saline) | | Administration: | Intraperitoneal injections; treated on an every other day schedule for 14 days | | Result: | Inhibited MM growth and prolongs host survival. |
| [IC 50]
SOD1: 1.07 μM (IC50) |
|
| Company Name: |
SynAsst Chemical.
|
| Tel: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|