| Identification | Back Directory | [Name]
H2L 5765834 | [CAS]
420841-84-5 | [Synonyms]
H2L 5765834
HFYPTENHTPNXGP-UHFFFAOYSA-N
2,3-Dihydro-2-[3-(4-nitrophenoxy)phenyl]-1,3-dioxo-1H-isoindole-5-carboxylic acid | [Molecular Formula]
C21H12N2O7 | [MDL Number]
MFCD01137741 | [MOL File]
420841-84-5.mol | [Molecular Weight]
404.33 |
| Chemical Properties | Back Directory | [Boiling point ]
665.8±65.0 °C(Predicted) | [density ]
1.544±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 4°C | [solubility ]
<40.43mg/ml in DMSO | [form ]
Solid | [pka]
3.31±0.20(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
H2L 5765834 (cas# 420841-84-5) is a novel LPA3 antagonist which may be used in treatment of systemic sclerosis. | [in vivo]
H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model[2]. | [IC 50]
LPA1 Receptor: 94 nM (IC50); LPA3 Receptor: 752 nM (IC50); LPA5 Receptor: 463 nM (IC50) | [storage]
Store at +4°C |
|
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Bide Pharmatech Ltd.
|
| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
| Company Name: |
nanjing
|
| Telephone: |
13376084917 13376082704 |
| Website: |
www.linye-e.com/ |
|