| Identification | Back Directory | [Name]
9H-Purin-6-amine, 2-fluoro-9-[2-(1-methylethoxy)ethyl]-8-[(3,4,5-trimethoxyphenyl)methyl]- | [CAS]
422508-27-8 | [Synonyms]
9H-Purin-6-amine, 2-fluoro-9-[2-(1-methylethoxy)ethyl]-8-[(3,4,5-trimethoxyphenyl)methyl]- | [Molecular Formula]
C20H26FN5O4 | [MOL File]
422508-27-8.mol | [Molecular Weight]
419.45 |
| Chemical Properties | Back Directory | [Boiling point ]
643.5±65.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100mg/mL | [form ]
powder | [pka]
1.66±0.10(Predicted) | [color ]
off-white |
| Hazard Information | Back Directory | [Uses]
A cell-permeable 6-amino-purine based compound that selectively binds to HSP90a (EC50 = 5.4 µM) and inhibits its activity in SKBr3 and MCF-7 breast cancer cells. Exhibits much reduced activity towards other paralogs (EC50 = 22.85, 71, and 173 5.4 µM for HSP90b, GRP94 AND Trap-1, respectively). Selectively depletes cytosolic HER2 and induces its redistribution towards lysosomes and early endosomes (~20 5.4 µM) without affecting membrane associated HER2. Does not appear to be toxic towards nonmalignant cells.
Please note that the molecular weight for this compound is batch-specific due to variable water content. | [Biological Activity]
Cell permeable: yes''Primary Target
HSP90a |
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| Company Name: |
Merck KGaA
|
| Telephone: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|