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4238-41-9

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4238-41-9 Structure

4238-41-9 Structure
IdentificationBack Directory
[Name]

TLCK
[CAS]

4238-41-9
[Synonyms]

TLCK
TLCK HCL
TOS-LYS-CMK HCL
TLCK HYDROCHLORIDE
TOS-LYS-CHLOROMETHYLKETONE HCL
TOSYL-L-LYSYL-CHLOROMETHANE HCL
TOSYL-L-LYSINE CHLOROMETHYLKETONE HCL
N-ALPHA-TOSYL-LYS-CHLOROMETHYLKETONE HCL
NALPHA-P-TOSYL-L-LYSIN CHLOROMETYL KETONE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-L-2-HEPTANONE
Chloro-3-tosylamido-7-amino-2-heptanone-HCl
1-Chloro-3-tosylamido-7-amino-2-heptanoneHCl
N-ALPHA-P-TOSYL-L-LYSIN CHLOROMETYL KETONE HCL
Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride
L-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HCL
Tosyllysine Chloromethyl Ketone (hydrochloride)
TLCK (Tosyl-L-lysyl-chloromethane hydrochloride)
N-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE
N-ALPHA-TOSYL-LYS CHLOROMETHYL KETONE, HYDROCHLORIDE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HYDROCHLORIDE
p-N-(7-amino-1-chloro-2-oxohept-3-yl)toluenesulphonamide
N-ALPHA-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-L-2-HEPTANONE HYDROCHLORIDE
N-ALPHA-P-TOSYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE
P-TOLUENESULFONYL-L-LYSINE CHLOROMETHYL KETONE HYDROCHLORIDE
1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTA NONE HYDROCHLORIDE 98%
(3S)-1-CHLORO-3-TOSYLAMIDO-7-AMINO-2-HEPTANONE HYDROCHLORIDE
(3S)-7-AMINO-1-CHLORO-3-TOSYLAMINO-2-HEPTANONE HYDROCHLORIDE
L-1-CHLORO-3-(4-TOSYLAMIDO)-7-AMINO-2-HEPTANONE HYDROCHLORIDE
Nalpha-(p-Toluenesulfonyl)-DL-lysine chloromethyl ketone hydrochloride
Nα-Tosyl-Lys Chloromethyl Ketone, Hydrochloride - CAS 4238-41-9 - Calbiochem
[EINECS(EC#)]

224-199-0
[Molecular Formula]

C14H22Cl2N2O3S
[MDL Number]

MFCD00065395
[MOL File]

4238-41-9.mol
[Molecular Weight]

369.3
Chemical PropertiesBack Directory
[Melting point ]

~165 °C (dec.)
[storage temp. ]

2-8°C
[solubility ]

H2O: 50 mg/mL
[form ]

powder
[color ]

white to pink
[Water Solubility ]

Soluble in water
[InChI]

1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
[InChIKey]

YFCUZWYIPBUQBD-ZOWNYOTGSA-N
[SMILES]

[S](=O)(=O)(N[C@@H](CCCC[N+H3])C(=O)CCl)c1ccc(cc1)C.[Cl-]
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26-36
[WGK Germany ]

3
[RTECS ]

XT5160000
[F ]

10-21
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

Inhibitor of papain and trypsin
[Biological Activity]

Cell permeable: no''EC50 = 80 μM blocking nitric oxide synthase induced by interferon-γ and lipopolysaccharides in macrophages''Primary Target
trypsin like proteases''Product does not compete with ATP.''Reversible: no
[IC 50]

Caspase-3: 12.0 μM (IC50); Caspase-7: 19.3 μM (IC50); Caspase-6: 54.5 μM (IC50)
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