| Identification | Back Directory | [Name]
BPV(PHEN) | [CAS]
42494-73-5 | [Synonyms]
BPV(PHEN)
K[VO(O2)2C12H8N2] 3H2O
bpV(phen) - CAS 42494-73-5 - Calbiochem
POTASSIUM BISPEROXO(1,10-PHENANTHROLINE)OXOVANADATE (V)
Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V) trihydrate | [Molecular Formula]
C12H8N2O5V.K | [MDL Number]
MFCD00676556 | [MOL File]
42494-73-5.mol | [Molecular Weight]
350.24 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
H2O: soluble20mg/mL, clear | [form ]
Yellow solid | [color ]
faint yellow to dark yellow | [Water Solubility ]
water: 5mg/mL | [InChI]
1S/C12H8N2.K.2H2O2.O.V/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;;2*1-2;;/h1-8H;;2*1-2H;;/q;+1;;;; | [InChIKey]
MQPXOTNOFVCXDA-UHFFFAOYSA-N | [SMILES]
O=[V]123([N]4=CC=CC5=C4C6=C(C=CC=[N]62)C=C5)(OO3)OO1.[K] |
| Hazard Information | Back Directory | [General Description]
The water content varies from lot to lot and is supplied on the label along with the lot-specific molecular weight. | [Biochem/physiol Actions]
bpV(phen) is an insulin receptor kinase (IRK) activator and an inhibitor of protein phosphotyrosine phosphatases with selectivity for PTEN, phosphatase and tensin homolog, a tumour suppressor phosphatase involved in cell cycle regulation. IC50 values for bpV(phen) are 38 nM for PTEN compared to 343 nM for PTPβ and 920 nM for PTP-1β. bpV(phen) has anti-inflammatory effects in oxidative stress including inhibitory effects on oxidative stress-induced cardiomyocyte injury that may be partially modulated by the action of ROS on PTEN. It may also be involved in differentiation. |
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