| Identification | Back Directory | [Name]
4-AMIDINOPYRIDINIUM CHLORIDE | [CAS]
42518-06-9 | [Synonyms]
BUTTPARK 32\03-56
4-AMIDINOPYRIDINIUM CHLORIDE
4-AMIDINOPYRIDINE HYDROCHLORIDE
ISONICOTINAMIDINE HYDROCHLORIDE
4-methylamidinopyridine chloride
4-AMIDINOPYRIDINIUM HYDROCHLORIDE
Isonicotinimidamide xhydrochloride
Isonicotinimidamide hydrochloride(1:x)
PYRIDINE-4-CARBOXIMIDAMIDE HYDRATE HCL
4-PYRIDINECARBOXIMIDAMIDE, HYDROCHLORIDE
PYRIDINE-4-CARBOXIMIDAMIDE HYDROCHLORIDE
Isonicotinimidamide hydrochloride hydrate
[amino(pyridin-4-yl)methylidene]ammonium chloride | [EINECS(EC#)]
692-231-4 | [Molecular Formula]
C6H8ClN3 | [MDL Number]
MFCD00040385 | [MOL File]
42518-06-9.mol | [Molecular Weight]
157.6 |
| Chemical Properties | Back Directory | [Melting point ]
263 °C | [storage temp. ]
Inert atmosphere,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C6H7N3.ClH/c7-6(8)5-1-3-9-4-2-5;/h1-4H,(H3,7,8);1H | [InChIKey]
IONKMFGAXKCLMI-UHFFFAOYSA-N | [SMILES]
C(C1=CC=NC=C1)(N)=N.Cl |
| Hazard Information | Back Directory | [Chemical Properties]
White to light brown solid | [Synthesis]
The general procedure for the synthesis of 4-formamidopyridine hydrochloride from 4-cyanopyridine was as follows: 4-cyanopyridine (20.0 g, 0.2 mol) was dissolved in anhydrous methanol (200 mL), followed by a one-time addition of powdered sodium methanol (1.1 g, 20 mmol). The reaction mixture was stirred at room temperature overnight. Next, ammonium chloride (16.5 g, 0.31 mol) was added and the reaction mixture was heated to reflux for 4 hours, after which it was cooled to room temperature. After the solvent was removed by evaporation, anhydrous ethanol (300 mL) was added. The mixture was heated to reflux and maintained for 15 min before the solid was removed by filtration. The filtrate was cooled to room temperature and allowed to stand overnight. The filtrate was filtered again to remove inorganic salts and the reaction mixture was subsequently concentrated to about one-third of the original volume to give 24.0 g (76% yield) of 4-formamidinopyridine hydrochloride by final filtration. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 15, p. 3487 - 3490
[2] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 11, p. 3347 - 3356
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 12, p. 2990 - 2993
[4] Journal of Medicinal Chemistry, 1990, vol. 33, # 4, p. 1230 - 1241
[5] Patent: US5294612, 1994, A |
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