| Identification | Back Directory | [Name]
H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH | [CAS]
425632-67-3 | [Synonyms]
H-Val-Pro-Leu-Ser-Leu-Tyr-Ser-Gly-OH
Glycine, L-valyl-L-prolyl-L-leucyl-L-seryl-L-leucyl-L-tyrosyl-L-seryl- | [Molecular Formula]
C39H62N8O12 | [MOL File]
425632-67-3.mol | [Molecular Weight]
834.96 |
| Hazard Information | Back Directory | [Uses]
VPLSLYSG is an octapeptide that can be degraded by matrix metalloproteinase-9 (MMP-9), MMP-1 and MMP-2. VPLSLYSG has potential applications in MMP substrates[1][2][3]. | [References]
[1] Suzuki H, et al. Accurate targeting of activated macrophages based on synergistic activation of functional molecules uptake by scavenger receptor and matrix metalloproteinase. ACS Chem Biol. 2008 Aug 15;3(8):471-9. DOI:10.1021/cb800067e
[2] Patterson J, et al. Enhanced proteolytic degradation of molecularly engineered PEG hydrogels in response to MMP-1 and MMP-2. Biomaterials. 2010 Oct;31(30):7836-45. DOI:10.1016/j.biomaterials.2010.06.061
[3] Wieduwild R, et al. Assembling and decorating hyaluronan hydrogels with twin protein superglues to mimic cell-cell interactions. Biomaterials. 2018 Oct;180:253-264. DOI:10.1016/j.biomaterials.2018.07.020 |
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