| Identification | Back Directory | [Name]
Phosphonic acid, P,P'-[2-(2-aminophenyl)-1-hydroxyethylidene]bis- | [CAS]
427899-21-6 | [Synonyms]
NE21650
NE-21650
NE 21650
Phosphonic acid, P,P'-[2-(2-aminophenyl)-1-hydroxyethylidene]bis- | [Molecular Formula]
C8H13NO7P2 | [MOL File]
427899-21-6.mol | [Molecular Weight]
297.14 |
| Hazard Information | Back Directory | [Uses]
NE21650 potently inhibits farnesyl diphosphate (FPP) synthase. NE21650 is a weak inhibitor of isopentenyl diphosphate (IPP) isomerase. NE21650 is a potent inhibitor of protein prenylation in osteoclasts and macrophages and bone resorption in vitro[1]. | [References]
[1] Keith Thompson, et al. Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase. Biochem Biophys Res Commun. 2002 Jan 18;290(2):869-73. DOI:10.1006/bbrc.2001.6289 |
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