| Identification | Back Directory | [Name]
4-Pyrimidinecarbonitrile (7CI,9CI)
| [CAS]
42839-04-3 | [Synonyms]
4-Cyanopyrimidine
4-Pyrimidinecarbonitrile
4-Pyrimidinecarbonitrile (7CI,9CI)
4-Pyrimidinecarbonitrile (7CI,9CI) ISO 9001：2015 REACH | [Molecular Formula]
C5H3N3 | [MDL Number]
MFCD07787613 | [MOL File]
42839-04-3.mol | [Molecular Weight]
105.1 |
| Chemical Properties | Back Directory | [Melting point ]
31 °C | [Boiling point ]
60 °C(Press: 5 Torr) | [density ]
1.22 | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
-2.02±0.10(Predicted) | [Appearance]
Off-white to light yellow Solid | [InChI]
InChI=1S/C5H3N3/c6-3-5-1-2-7-4-8-5/h1-2,4H | [InChIKey]
ZIEWSZYVEDTXGH-UHFFFAOYSA-N | [SMILES]
C1=NC=CC(C#N)=N1 |
| Hazard Information | Back Directory | [Synthesis]
4-Cyanopyrimidine is synthesized from β-keto esters via conversion to an acetal, hydrolysis to an oxime, followed by chlorination and dehydration using POCl3/2-picoline to form a nitrile intermediate, and final treatment with NH4OH in THF[1].
 | [References]
[1]
Nugent, R. A., Schlachter, S. T., Murphy, M. J., Cleek, G. J., Poel, T. J., Wishka, D. G., Graber, D. R., Yagi, Y., Keiser, B. J., Olmsted, R. A., Kopta, L. A., Swaney, S. M., Poppe, S. M., Morris, J., Tarpley, W. G., Thomas, R. C. (1998). Pyrimidine Thioethers: A Novel Class of HIV-1 Reverse Transcriptase Inhibitors with Activity Against BHAP-Resistant HIV. Journal of Medicinal Chemistry, 41(20), 3793–3803. https://doi.org/10.1021/jm9800806
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Tetranov Biopharm
|
| Telephone: |
13526569071 |
| Website: |
http://www.leadmedpharm.com/index.html |
| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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