| Identification | Back Directory | [Name]
4,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-3-amine | [CAS]
42951-68-8 | [Synonyms]
4,6-diphenyl-1H-pyrazolo[3,4-b]pyridin-3-amine
1H-Pyrazolo[3,4-b]pyridin-3-amine, 4,6-diphenyl- | [Molecular Formula]
C18H14N4 | [MOL File]
42951-68-8.mol | [Molecular Weight]
286.33 |
| Hazard Information | Back Directory | [Description]
EB1 is a binding partner of the tumor suppressor adenomatous polyposis coli (APC). APC binding to EB1 promotes EB1 association with microtubule ends and microtubule stabilization | [Uses]
EB1 is the inhibitor of kinases MNK with IC50s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation[1][2]. | [IC 50]
MNK1: 0.69 μM (IC50); MNK2: 9.4 μM (IC50); eIF4E | [References]
[1] Bou-Petit E, et al. Overcoming Paradoxical Kinase Priming by a Novel MNK1 Inhibitor. J Med Chem. 2022 Apr 28;65(8):6070-6087. DOI:10.1021/acs.jmedchem.1c01941
[2] Aboukhatwa SM, et al. Nicotinonitrile-derived apoptotic inducers: Design, synthesis, X-ray crystal structure and Pim kinase inhibition. Bioorg Chem. 2022 Dec;129:106126. DOI:10.1016/j.bioorg.2022.106126 |
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