| Identification | Back Directory | [Name]
(E)-9-octadecenamide | [CAS]
4303-70-2 | [Synonyms]
Elaidoylamide
Elaidic AMide
Einecs 224-316-5
(E)-9-octadecenamide
(9E)-9-OctadecenaMide
trans-9-OctadecenaMide | [EINECS(EC#)]
224-316-5 | [Molecular Formula]
C18H35NO | [MOL File]
4303-70-2.mol | [Molecular Weight]
281.477 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
84-85°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 2mg/mL; DMF:PBS (pH 7.2) (1:1): 0.5mg/mL | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Structural analog of oleamide (cis-9,10-octadecenoamide), a sleep-inducing fatty acid amide found naturally in cerebrospinal fluid.
| [Description]
Elaidamide is a fatty acid amide that has been found in the cerebrospinal fluid of sleep-deprived cats. It inhibits rat microsomal epoxide hydrolase (mEH; Ki = 70 nM). Elaidamide also inhibits porcine pancreatic and human synovial phospholipase A2 (PLA2). In vivo, elaidamide (10 mg/animal) induces physiological sleep in rats. | [Definition]
ChEBI: Elaidamide is a fatty amide. | [storage]
Store at -20°C | [References]
[1] BENJAMIN F. CRAVATT. Chemical Characterization of a Family of Brain Lipids That Induce Sleep[J]. Science, 1995, 268 5216. DOI: 10.1126/science.7770779
[2] CHRISTOPHE MORISSEAU. Inhibition of Microsomal Epoxide Hydrolases by Ureas, Amides, and Amines[J]. Chemical Research in Toxicology, 2001, 14 4: 409-415. DOI: 10.1021/tx0001732
[3] MAHENDRA K. JAIN. Fatty acid amides: scooting mode-based discovery of tight-binding competitive inhibitors of secreted phospholipases A2[J]. Journal of Medicinal Chemistry, 1992, 35 19: 3584-3586. DOI: 10.1021/jm00097a018 |
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