| Identification | Back Directory | [Name]
4-BROMO-2-METHOXYBENZALDEHYDE | [CAS]
43192-33-2 | [Synonyms]
2-Methoxy-4-broMobenzaldehyde
Benzaldehyde, 4-bromo-2-methoxy-
4-Bromo-2-methoxybenzaldehyde 98%
4-BroMo-2-Methoxybenzaldehyde, 97%+
5-Bromo-2-formylanisole, 4-Bromo-o-anisaldehyde | [Molecular Formula]
C8H7BrO2 | [MDL Number]
MFCD08276823 | [MOL File]
43192-33-2.mol | [Molecular Weight]
215.05 |
| Chemical Properties | Back Directory | [Melting point ]
67-71 °C
| [Boiling point ]
52-54 °C(Press: 0.04 Torr) | [density ]
1.522±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
solid | [Appearance]
White to off-white Solid | [Water Solubility ]
Soluble in water. | [Sensitive ]
Air Sensitive | [InChI]
InChI=1S/C8H7BrO2/c1-11-8-4-7(9)3-2-6(8)5-10/h2-5H,1H3 | [InChIKey]
YMXQYZABFWVXEK-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=C(Br)C=C1OC |
| Hazard Information | Back Directory | [Chemical Properties]
off-white solid | [Uses]
Building block in the synthesis of a nonacid degradable linker for solid-phase synthesis. | [Uses]
4-Bromo-2-methoxybenzaldehyde is used in the building block, synthesis of a nonacid degradable linker for solid-phase synthesis. | [Synthesis]
A synthesis of 4-bromo-2-methoxybenzaldehyde is reported from 1,4 dibromo 2-fluorobenzene. First, 2-fluoro-4-bromobenzaldehyde is prepared through metal halogen exchange and formylation with a formyl source at 0° C. After crystallization, this intermediate is reacted with methanol in the presence of potassium carbonate. Subsequently, 4-bromo-2-methoxy-benzaldehyde is crystallized.
| [References]
[1] Patent: WO2017/182495, 2017, A1. Location in patent: Page/Page column 141-142
[2] Patent: WO2005/63756, 2005, A1. Location in patent: Page/Page column 33-34
[3] Organic Letters, 2017, vol. 19, # 19, p. 5122 - 5125
[4] Patent: WO2009/158426, 2009, A1. Location in patent: Page/Page column 64-65 |
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Alfa Aesar
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Energy Chemical
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www.energy-chemical.com |
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Jia Xing Isenchem Co.,Ltd
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