| Identification | Back Directory | [Name]
Skp2 Inhibitor C1 | [CAS]
432001-69-9 | [Synonyms]
CS-1230
SKPin C1
MDK-1699
Skp2-IN-C1
kp2 Inhibitor C1
Skp2 Inhibitor C1
Skp2 inhibitor C1 (SKPin C1)
2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Acetic acid, 2-[4-bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]- | [Molecular Formula]
C18H13BrN2O4S2 | [MDL Number]
MFCD03705291 | [MOL File]
432001-69-9.mol | [Molecular Weight]
465.34 |
| Chemical Properties | Back Directory | [Boiling point ]
655.3±65.0 °C(Predicted) | [density ]
1.74±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 10 mg/mL | [form ]
A crystalline solid | [pka]
2.97±0.10(Predicted) | [color ]
White to yellow | [InChI]
1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7- | [InChIKey]
IYCJJVVXEHZJHE-CHHVJCJISA-N | [SMILES]
S1\C(=C/c3c(ccc(c3)Br)OCC(=O)O)\C(=O)N(C1=S)Cc2cnccc2 |
| Hazard Information | Back Directory | [Uses]
SKPin C1 is a small molecule Skp-2-mediated p27 degradation inhibitor. | [Biological Activity]
Cell permeable: yes''Primary Target
disrupts p27-Skp2 interaction''Reversible: yes | [in vivo]
Skp2 Inhibitor C1 (5 mg/kg and 10 mg/kg; 3 times within 24 h: 24, 5, and 1 h before the test) shows the antidepressant-like effect in mouse models following chronic treatment by using the tail suspension test (TST), forced swimming test (FST), and social interaction test (SIT)[2].
|
|
| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
|