432047-36-4

944993-06-0

432047-36-4

The general procedure for the synthesis of 1-(2-thiazolyl)ethylamine from 2-acetylthiazole oxime is as follows: Preparative Example 2: Synthesis of 1-(1,3-thiazol-2-yl)-1-ethylamine A solution was prepared by dissolving 1-(1,3-thiazol-2-yl)-1-ethanone oxime (710 mg) in methanol (10 mL). To this solution, ammonium chloride (1.35 g) and zinc powder (6.5 g) were added sequentially and the mixture was heated under reflux conditions for 2 hours. After completion of the reaction, 10% sodium hydroxide solution (10 mL) was added to the mixture and extracted three times with chloroform. The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure and the resulting product was dried by vacuum pump to give 1-(2-thiazolyl)ethylamine (580 mg, 91% yield). Product characterization data: 1H-NMR (CDCl3): δ 1.55 (d, J = 6.8 Hz, 3H), 4.43 (q, J = 6.8 Hz, 1H), 7.24 (d, J = 3.4 Hz, 1H), 7.71 (d, J = 3.2 Hz, 1H).