| Identification | Back Directory | [Name]
3β-Hydroxy-5β-carda-14,20(22)-dienolide | [CAS]
4321-20-4 | [Synonyms]
14-Anhydrodigitoxigenin
3β-Hydroxy-5β-carda-14,20(22)-dienolide | [Molecular Formula]
C23H32O3 | [MOL File]
4321-20-4.mol | [Molecular Weight]
356.5 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
14-Anhydrodigitoxigenin is a cardenolide and a derivative of digitoxin.1 It reduces the activity of guinea pig heart Na+/K+-ATPase by 15% when used at a concentration of 10 μM.2 | [Uses]
14-Anhydrodigitoxigenin is a cardenolides that can be isolated from the leaves of Acokanthera oblongifolia. 14-Anhydrodigitoxigenin is a Na+/K+-ATPase inhibitor[1]. | [storage]
Store at -20°C | [References]
1. Kamano, Y., Tozawa, M., and Pettit, G.R. Steroids and related natural products. 90. 15β-Hydroxydigitoxigenin J. Org. Chem. 40(6),793-796(1975).
2. Megges, R., Weiland, J., Sch?n, R., et al. Cardenamides from cardenolides: Cardiac and anticancer activities Collect. Czech. Commun. 67(3),336-352(2002). |
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