| | Identification | Back Directory |  | [Name] 
 4E2RCat
 |  | [CAS] 
 432499-63-3
 |  | [Synonyms] 
 4E2RCat
 Eukaryotic Initiation Factor
 Benzoic acid, 2-chloro-5-[5-[[4-oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-
 |  | [Molecular Formula] 
 C22H14ClNO4S2
 |  | [MDL Number] 
 MFCD03706106
 |  | [MOL File] 
 432499-63-3.mol
 |  | [Molecular Weight] 
 455.93
 | 
 | Chemical Properties | Back Directory |  | [Boiling point ] 
 659.0±65.0 °C(Predicted)
 |  | [density ] 
 1.56±0.1 g/cm3(Predicted)
 |  | [storage temp. ] 
 Store at -20°C
 |  | [solubility ] 
 DMSO : 15.5 mg/mL (34.00 mM)
 |  | [form ] 
 Solid
 |  | [pka] 
 2.72±0.25(Predicted)
 |  | [color ] 
 Light yellow to yellow
 | 
 | Hazard Information | Back Directory |  | [Uses] 
 4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
 |  | [in vivo] 
 
 4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death[1]. |  | [IC 50] 
 eIF4
 |  | [References] 
 [1] Cencic R, et al. Blocking eIF4E-eIF4G interaction as a strategy to impair coronavirus replication. J Virol. 2011 Jul;85(13):6381-9. DOI:10.1128/JVI.00078-11
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