| Identification | Back Directory | [Name]
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- | [CAS]
433234-16-3 | [Synonyms]
SMI-6860766
TRAFSTOP6860766
TRAFSTOP 6860766
TRAF-STOP 6860766
2-Propen-1-one, 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl- | [Molecular Formula]
C15H11BrClNO | [MOL File]
433234-16-3.mol | [Molecular Weight]
336.61 |
| Chemical Properties | Back Directory | [Boiling point ]
417.5±45.0 °C(Predicted) | [density ]
1.509±0.06 g/cm3(Predicted) | [solubility ]
Acetonitrile: Slightly soluble: 0.1-1 mg/ml | [pka]
-1.69±0.70(Predicted) |
| Hazard Information | Back Directory | [Description]
SMI-6860766 is a blocker of CD40-Traf6 interactions. It acts by ameliorating the complications of diet induced obesity in mice. | [Uses]
SMI 6860766, a small molecule inhibitor of CD40-TRAF6 interaction, improves glucose tolerance, reduces immune cell accumulation in adipose tissue, and reduces AT inflammation[1]. | [in vivo]
SMI 6860766 increases the number of adipocytes per field of view by 15.3% in mouse EpAT, indicating that SMI reduces adipocyte size, indicating reduces lipid storage and improves metabolic function[1].
SMI 6860766 reduces the number of total leukocytes (CD45+ cells) in mouse EpAT by 68.5%[1].
SMI 6860766 does not induce differences in hepatosteatosis[1]. | [References]
[1] Van den Berg SM, et al. Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice. Int J Obes (Lond). 2015 May;39(5):782-90. DOI:10.1038/ijo.2014.198 |
|
|