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433289-83-9

433289-83-9 Structure

433289-83-9 Structure
IdentificationBack Directory
[Name]

Atorvastatin Related Compound A (20 mg) (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl-4,5- diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt)
[CAS]

433289-83-9
[Synonyms]

USP Impurity A
Atorvastatin calcium-1
Atorvastatin Impurity A
Atorvastatin EP IMpurity A
ATORVASTATIN DESFLUORO IMPURITY
Atorvastatin Related CoMpound A
Atorvastatin Calcium Impurity A
Desfluoro Atorvastatin SodiuM Salt
Atorvastatin USP Related Compound A
Desfluoro Atorvastatin Calcium Salt
Atorvastatin EP ImpurityABCDEFGHJKL
USP Atorvastatin Related Compound A
Defluorocarbon atorvastatin calcium
(3R,5R)-3,5-dihydroxy-7-(2-isopropyl-
Atorvastatin Calcium Hydrate impurity 22
"Defluoridated atorvastatin calcium" Atorvastatin calcium 2020 Pharmacopoeia impurity I)“
Calcium (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)h
calciuM (3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbaMoyl)-1H-pyrrol-1-yl)heptanoate
Calcium bis{(3R,5R)-3,5-dihydroxy-7-[2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl]heptanoate}
((3R,5R)-3,5-dihydroxy-7-(2-isopropyl-4,5-diphenyl-3- (phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate) calcium(II)
Atorvastatin Related Compound A (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl- (1044527)
(βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt
(βR,δR)-β,δ-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid Calcium Salt (2:1)
Desfluoro iMpurity, or (3R,5R)-7-[3-(phenylcarbaMoyl)-2-isopropyl-4,5-diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calciuM salt
(betaR,deltaR)-beta,delta-Dihydroxy-2-(1-methylethyl)-4,5-diphenyl-3-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1)
Atorvastatin Related Compound A (20 mg) (Desfluoro impurity, or (3R,5R)-7-[3-(phenylcarbamoyl)-2-isopropyl-4,5- diphenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid calcium salt)
Atorvastatin impurity 4/Atorvastatin EP Impurity A Calcium Salt/Defluoro Atorvastatin Calcium Salt/(3R,5R)-3,5-Dihydroxy-7-(2-isopropyl-4,5-diphenyl-3-(phenylcarbamoyl)-1H-pyrrol-1-yl)heptanoate, calcium salt (2:1)
Atorvastatin EP Impurity AQ: What is Atorvastatin EP Impurity A Q: What is the CAS Number of Atorvastatin EP Impurity A Q: What is the storage condition of Atorvastatin EP Impurity A Q: What are the applications of Atorvastatin EP Impurity A
[Molecular Formula]

C33H35CaN2O5+
[MDL Number]

MFCD11977955
[MOL File]

433289-83-9.mol
[Molecular Weight]

579.719
Chemical PropertiesBack Directory
[Melting point ]

150℃ (decomposition)
[storage temp. ]

2-8°C
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

neat
[Stability:]

Hygroscopic
[Major Application]

pharmaceutical small molecule
[InChIKey]

HBFCHKRJRYFUBH-QXFSHCJSNA-M
[SMILES]

c1(-c2ccccc2)c(C(=O)Nc2ccccc2)c(C(C)C)[n](CC[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c1ccccc1.[Ca+2] |&1:24,27,r|
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P264-P271-P280-P302+P352-P305+P351+P338
[Hazard Codes ]

Xi
[Risk Statements ]

36/37/38
[Safety Statements ]

26
[WGK Germany ]

WGK 2
[HS Code ]

2933997500
[Storage Class]

11 - Combustible Solids
[Hazard Classifications]

Aquatic Chronic 2
STOT RE 2
Hazard InformationBack Directory
[Uses]

Desfluoro Atorvastatin is an impurity in the synthesis of Atorvastatin (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
[Synthesis]

Transfer [R,(R*,R*)]-2-(4-fluorophenyl)-β,α-dihydroxy-5-(1-methylethyl)-3-phenyl-[(anilino)-hydroxy]-1H-pyrrole-1-heptanoic acid sodium salt solution into 10L clean and dry kettle, and then add 3L of methanol into the kettle, and raise the temperature to
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