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433966-92-8

433966-92-8 Structure

433966-92-8 Structure
IdentificationBack Directory
[Name]

1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine
[CAS]

433966-92-8
[Synonyms]

AE 51310
1-(2,5-dichloro-4-methoxyphenyl)sulfonyl-3-methylpiperidine
Piperidine, 1-[(2,5-dichloro-4-methoxyphenyl)sulfonyl]-3-methyl-
[Molecular Formula]

C13H17Cl2NO3S
[MOL File]

433966-92-8.mol
[Molecular Weight]

338.25
Chemical PropertiesBack Directory
[Boiling point ]

452.3±55.0 °C(Predicted)
[density ]

1.338±0.06 g/cm3(Predicted)
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (>25 mg/ml)
[form ]

solid
[pka]

-5.74±0.40(Predicted)
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard InformationBack Directory
[Description]

AE 51310 (433966-92-8) is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4).1 OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to bind Ga11 in lung cancer cells modulating PKC activation leading to activation of BRAF/MEK/ERK signaling pathways. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.2
[Uses]

AE 51310 is an OPN4 inhibitor. AE 51310 inhibits the activation of PKC and the downstream BRAF/MEK/ERKs signaling pathway. AE 51310 can be used for cancer research, such as NSCLC[1].
[References]

Jones et al. (2013), Small-molecule antagonists of melanopsin-mediated phototransduction; Nat. Chem. Biol. 9 630 Wang et al. (2020), Targeting Opsin4/Melanopsin with a Novel Small Molecule Suppresses PKC/RAF/MEK/ERK Signaling and Inhibits Lung Adenocarcinoma Progression; Mol. Cancer Res. 18 1028
433966-92-8 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Enzo Biochem Inc  
Tel: Enzo Biochem Inc. 13797054060
Website: www.enzo.com
Company Name: Focus Biomolecules  
Tel: 855-362-8721
Website: www.focusbiomolecules.com
Company Name: OTAVA chemicals  
Tel: 416 305 9979 (Canada)
Website: www.otavachemicals.com
Tags:433966-92-8 Related Product Information
860352-01-8 2301866-59-9 522-51-0 57226-68-3

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