| Hazard Information | Back Directory | [Uses]
Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1]. | [in vivo]
Avasopasem manganese is an agent intended to interrupt severe oral mucositis pathogenesis, to reduce the duration, incidence, and severity of radiation-induced oral mucositis[1]. | [References]
[1] Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38(3):288]. J Clin Oncol. 2019;37(34):3256-3265. DOI:10.1200/JCO.19.01507 |
|
|