| Identification | Back Directory | [Name]
PERAKINE | [CAS]
4382-56-3 | [Synonyms]
PERAKINE
Aids003043
Aids-003043
Raucaffrine
Indole alkaloid
(17R,20α)-19-Oxo-1,2-didehydro-1-demethyl-21β-methyl-18-norajmalan-17-ol acetate
18-Norajmalan-19-al, 17-(acetyloxy)-1,2-didehydro-1-demethyl-21-methyl-, (17R,20A,21B)-
18-Norajmalan-19-al, 17-(acetyloxy)-1,2-didehydro-1-demethyl-21-methyl-, (17R,20α,21β)-
(13R)-13-Acetyloxy-7aα,2α,6α-ethan[1]yl[2]ylidene-1,2,3,4,6,7,7a,12bβ-octahydro-4α-methylindolo[2,3-a]quinolizine-3β-carbaldehyde | [Molecular Formula]
C21H22N2O3 | [MDL Number]
MFCD32664419 | [MOL File]
4382-56-3.mol | [Molecular Weight]
350.42 |
| Chemical Properties | Back Directory | [Melting point ]
186 °C | [Boiling point ]
492.8±45.0 °C(Predicted) | [density ]
1.59±0.1 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
5.38±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
This alkaloid has been shown to be identical with Perakine (q.v.). | [Uses]
Perakine is an alkaloid extracted from family of Rauvolfia plants which acts as an inhibitor of aldose reductase, a potent drug target for diabetes. | [Definition]
ChEBI: An indole alkaloid having a ajmalan-type skeleton and characterised by a 17alpha-acetoxy group, a 21beta-methyl group, loss of the 1-methyl group with associated unsaturation at N(1)2C(2), and a 20alph
-formyl group in place of the 20beta-ethyl side-chain. | [References]
Khan, Khan, Siddiqui., Pakistan 1. Sci. Ind. Res., 8, 23 (1965) |
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