| Identification | Back Directory | [Name]
2-ethyl-1-hydroxy-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile | [CAS]
442567-43-3 | [Synonyms]
GNF7686
GNF-7686
GNF 7686
2-ethyl-1-hydroxy-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile | [Molecular Formula]
C15H13N3O | [MOL File]
442567-43-3.mol | [Molecular Weight]
251.28 |
| Hazard Information | Back Directory | [Description]
GNF7686 is a novel inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease. | [Uses]
GNF7686 is a cytochrome b inhibitor. GNF7686 exhibits inhibitory activity against complex III in the extracts of L. donovani and T. cruzi[1]. | [References]
[1] Wall RJ, et al. The Q Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani. ACS Infect Dis. 2020 Mar 13;6(3):515-528. DOI:10.1021/acsinfecdis.9b00426 |
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