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442567-43-3

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442567-43-3 Structure

442567-43-3 Structure
IdentificationBack Directory
[Name]

2-ethyl-1-hydroxy-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile
[CAS]

442567-43-3
[Synonyms]

GNF7686
GNF-7686
GNF 7686
2-ethyl-1-hydroxy-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile
[Molecular Formula]

C15H13N3O
[MOL File]

442567-43-3.mol
[Molecular Weight]

251.28
Chemical PropertiesBack Directory
[density ]

1.27±0.1 g/cm3(Predicted)
[pka]

3.45±0.53(Predicted)
Hazard InformationBack Directory
[Description]

GNF7686 is a novel inhibitor of Trypanosoma cruzi, the causative agent of Chagas disease.
[Uses]

GNF7686 is a cytochrome b inhibitor. GNF7686 exhibits inhibitory activity against complex III in the extracts of L. donovani and T. cruzi[1].
[References]

[1] Wall RJ, et al. The Q Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani. ACS Infect Dis. 2020 Mar 13;6(3):515-528. DOI:10.1021/acsinfecdis.9b00426
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