| Identification | Back Directory | [Name]
Benzamide, N-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-3,4-dimethoxy- | [CAS]
442898-75-1 | [Synonyms]
WAY-326817
HSP90-IN-22
N-(2-(4-Ethylpiperazin-1-yl)-4-methylquinolin-6-yl)-3,4-dimethoxybenzamide
Benzamide, N-[2-(4-ethyl-1-piperazinyl)-4-methyl-6-quinolinyl]-3,4-dimethoxy- | [Molecular Formula]
C25H30N4O3 | [MOL File]
442898-75-1.mol | [Molecular Weight]
434.53 |
| Chemical Properties | Back Directory | [Boiling point ]
574.9±50.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.38±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor with antiproliferative properties on cells with IC50 values of 3.65 μM for MCF7 breast cancer cells and 2.71 μM for SKBr3 breast cancer cells, respectively. | [References]
[1] Jiang F, et al. Identification and optimization of novel 6-acylamino-2-aminoquinolines as potent Hsp90 C-terminal inhibitors. Eur J Med Chem. 2017 Dec 1;141:1-14. DOI:10.1016/j.ejmech.2017.07.080 |
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