| Identification | Back Directory | [Name]
HDMAPP (ammonium salt) | [CAS]
443892-56-6 | [Synonyms]
HMBPP triammonium
HMB-?PP triammonium
HDMAPP (ammonium salt)
HMBPP triammonium salt
HMB-?PP triammonium salt
YPBALCNFFTVQJJ-JZWSQSCTSA-N | [Molecular Formula]
C5H15NO8P2 | [MOL File]
443892-56-6.mol | [Molecular Weight]
279.12 |
| Hazard Information | Back Directory | [Description]
HMBPP triammonium is a stimulator of gamma delta T cells. | [Uses]
(E)-4-Hydroxy-3-methylbut-2-en-1-yl Trihydrogen Diphosphate Triammonium Salt can be useful in the study of innate IL-23/Type 17 immune responses in childhood asthma. | [in vivo]
HDMAPP triammonium (compound 3E) (0.02-2.5 mg/kg; iv; 15 days) significantly increases γδ cells in a cynomolgus monkey model[1].
| Animal Model: | Nonhuman Primate Model in Cynomolgus[1] | | Dosage: | 0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg | | Administration: | Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days | | Result: | Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 2.5 mg/kg. |
| [IC 50]
TNFRSF1A | [storage]
Store at -20°C |
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