| Identification | Back Directory | [Name]
SB-681323 | [CAS]
444606-18-2 | [Synonyms]
GW 681323
SB-681323
DilMapiMod
SB-681323; GW 681323
Dilmapimod (SB-681323)
p38 MAPK,inhibit,Dilmapimod,SB681323,SB 681323,GW681323,GW-681323,Autophagy,Inhibitor
8-(2,6-Difluorophenyl)-2-((1,3-dihydroxypropan-2-yl)amino)-4-(4-fluoro-2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one
8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-Pyrido[2,3-d]pyrimidin-7(8H)-one
Pyrido[2,3-d]pyrimidin-7(8H)-one, 8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-2-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]- | [Molecular Formula]
C23H19F3N4O3 | [MDL Number]
MFCD16659063 | [MOL File]
444606-18-2.mol | [Molecular Weight]
456.42 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:125.0(Max Conc. mg/mL);273.87(Max Conc. mM) | [form ]
Solid | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease. | [References]
[1] Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100. DOI:10.1177/0091270009347873 |
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DebyeTec.com Inc.
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SPIRO PHARMA
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ChemeGen
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Bide Pharmatech Ltd.
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InvivoChem
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