| Identification | Back Directory | [Name]
Benzenemethanol, 4-[4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl]-2-chloro- | [CAS]
444725-49-9 | [Synonyms]
PD89211
PD-89211
PD 89211
Benzenemethanol, 4-[4-(1H-benzimidazol-2-ylmethyl)-1-piperazinyl]-2-chloro- | [Molecular Formula]
C19H21ClN4O | [MOL File]
444725-49-9.mol | [Molecular Weight]
356.85 |
| Hazard Information | Back Directory | [Uses]
PD-89211 is a selective dopamine D4 receptor antagonist with a Ki value of 3.7 nM. PD-89211 reverses Quinpirole (HY-B1752A)-induced [3H]thymidine uptake in CHOpro5 cells (IC50 = 2.1 nM). PD-89211 regulates dopamine/norepinephrine metabolism in the hippocampus and can be used for research on central nervous system disorders such as schizophrenia[1]. | [References]
[1] Pugsley TA, et al. The discovery of PD 89211 and related compounds: selective dopamine D4 receptor antagonists. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):219-26. DOI:10.1016/s0278-5846(01)00252-4 |
|
|