| Chemical Properties | Back Directory | [density ]
1.178±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: soluble; Ethanol: soluble | [form ]
A film | [pka]
11.77±0.60(Predicted) |
| Hazard Information | Back Directory | [Description]
16-epi Latrunculin B, first isolated from the Red Sea sponge N. magnifica, is a stereoisomer of the actin polymerization inhibitor, latrunculin B .1,2 At 5-10 μg/ml, 16-epi latrunculin B can disrupt microfilament activity in an actin disruption assay.2 It also demonstrates cytotoxic activity in mouse KA31T and NIH3T3 tumor cells (GI50s = 1 and 4 μg/ml, respectively) and antiviral activity against herpes simplex type 1 virus (ED50 = 1 μg/ml).1 | [Uses]
16-epi-latrunculin B is anticancer agent, which can inhibit the growth of HeLa cells with IC50 value of 3.9 uM[1]. 16-epi-latrunculin B has antiviral activity against HSV-1 (ED50 of 1 μg/mL)[2]. | [storage]
Store at -20°C | [References]
1. Hoye, T.R., Ayyad, S.E.N., Eklov, B.M., et al. Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B J. Am. Chem. Soc. 124(25),7405-7410(2016).
2. Vilozny, B., Amagata, T., Mooberry, S.L., et al. A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica J. Nat. Prod. 67(6),1055-1057(2004). |
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TargetMol
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400-821-0310 15002144251 |
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www.targetmol.cn/ |
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