| Identification | Back Directory | [Name]
N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide | [CAS]
445000-45-3 | [Synonyms]
N-(2-benzoylphenyl)-5-bromo-2-thiophenecarboxamide | [Molecular Formula]
C18H12BrNO2S | [MOL File]
445000-45-3.mol | [Molecular Weight]
386.262 |
| Hazard Information | Back Directory | [Uses]
BBT is an enhancer of impaired glucose-stimulated insulin secretion (GSIS). BBT exhibits anti-hyperglycemia activity, and protects β-cells from cytokine- or streptozotocin (STZ (HY-13753))-induced cell death in type 2 diabetes models. BBT acts function via cAMP/PKA and long-lasting (L-type) voltage-dependent Ca2+ channel/CaMK2 pathway[1]. | [References]
[1] Yao XG, et al. BBT improves glucose homeostasis by ameliorating cell dysfunction in type 2 diabetic mice. J Endocrinol. 2015 Mar;224(3):327-41. DOI:10.1530/JOE-14-0721 |
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