| Identification | Back Directory | [Name]
N-mesityl-2-(3-oxoindeno[1,2,3-de]phthalazin-2(3H)-yl)acetamide | [CAS]
445218-34-8 | [Synonyms]
N-mesityl-2-(3-oxoindeno[1,2,3-de]phthalazin-2(3H)-yl)acetamide | [Molecular Formula]
C25H21N3O2 | [MOL File]
445218-34-8.mol | [Molecular Weight]
395.453 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear (Warmed) | [form ]
Solid | [color ]
White to yellow | [InChIKey]
MVMNMAWCMNMLEC-UHFFFAOYSA-N | [SMILES]
O=C1C2=C(C(C3=C4C=CC=C3)=NN1CC(NC5=C(C)C=C(C)C=C5C)=O)C4=CC=C2 |
| Hazard Information | Back Directory | [Uses]
CNS-11 is a blood-brain barrier permeable tau fibril-degrading compound. CNS-11 reduces α-synuclein. CNS-11 can be used in Alzheimer's and Parkinson's disease research[1][2]. | [Biological Activity]
Brain tissue penetrant alpha-synuclein ligand th at potently disaggregate alpha-synuclein fibrils in vitro and in vivo models.
CNS-11 is brain tissue penetrant alpha-synuclein ligand th at potently disaggregate alpha-synuclein fibrils in vitro and in vivo models. CNS-11 inhibits intracellular seeding of a-synuclein fibrils in biosensor cells—HEK293T cells. C-11 reduces number of a-synuclein aggregates in C. elegans model. | [in vivo]
CNS-11 (1 mg/kg; i.v.,; once) is detected in the plasma and brain tissue of C57BL/6J mice, indicating brain permeability[2].
| [References]
[1] Paul M Seidler, et al. Structure-based discovery of small molecules that disaggregate Alzheimer's disease tissue derived tau fibrils in vitro. Nat Commun. 2022 Sep 16;13(1):5451. DOI:10.1038/s41467-022-32951-4
[2] Murray KA, et al. Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils. Proc Natl Acad Sci U S A. 2023 Feb 14;120(7):e2217835120. DOI:10.1073/pnas.2217835120 |
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Merck KGaA
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www.sigmaaldrich.cn |
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Specs
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www.specs.net |
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