| Identification | Back Directory | [Name]
4-[2-(benzylamino)-2-oxoethoxy]-N-(2,3-dimethylphenyl)benzamide | [CAS]
446306-43-0 | [Synonyms]
4-[2-(benzylamino)-2-oxoethoxy]-N-(2,3-dimethylphenyl)benzamide | [Molecular Formula]
C24H24N2O3 | [MOL File]
446306-43-0.mol | [Molecular Weight]
388.46 |
| Chemical Properties | Back Directory | [Boiling point ]
571.9±50.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13?+-.0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MEISi-1 is a novel MEIS inhibitor (MEISi), significantly inhibiting MEIS-luciferase reporters in vitro and inducing murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo. | [Uses]
MEISi-1 is a homeodomain inhibitor of small molecule MEIS1 protein. MEISi-1 significantly inhibited the activity of luciferase reporter genes containing MEIS binding sites (TGACAG) and induced self-renewal of mouse and human HSCS in vitro and in vivo. MEISi-1 can be used for research in blood diseases, heart regeneration and cancer[1]. | [References]
[1] Turan R D, et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity[J]. Scientific reports, 2020, 10(1): 7994. DOI:10.1038/s41598-020-64888-3 |
|
| Company Name: |
OTAVA chemicals
|
| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
| Company Name: |
Specs
|
| Tel: |
+31 15 251 8111 |
| Website: |
www.specs.net |
|