| Chemical Properties | Back Directory | [Boiling point ]
632.4±55.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
3.15±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
GC 14 is a thyroid hormone antagonist. GC 14 contains extensions at the 5′-position of the outer thyronine ring or from the bridging carbon and has only a modest affinity and potency for the thyroid hormone receptor (TR) that limits studies of their antagonistic actions[2]. | [Uses]
GC 14 is a selective thyroid hormone receptor antagonist, with IC50 values of 35 nM and 200 nM for hTRβ and hTRα, respectively. | [storage]
Store at -20°C | [References]
[1]. Chiellini G, et al. Synthesis and biological activity of novel thyroid hormone analogues: 5'-aryl substituted GC-1 derivatives. Bioorg Med Chem. 2002 Feb;10(2):333-46. [2]. Nguyen NH, et al. Rational design and synthesis of a novel thyroid hormone antagonist that blocks coactivator recruitment. J Med Chem. 2002 Jul 18;45(15):3310-20. |
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