| Identification | Back Directory | [Name]
5-formyl-2'-deoxyuridine | [CAS]
4494-26-2 | [Synonyms]
5-Formyl-dU
5-formyl-2'-dU
α-Oxothymidine
Thymidine, α-oxo-
2'-deoxy-5-forMyluridine
5-formyl-2'-deoxyuridine
1-(2-Deoxy-β-D-ribofuranosyl)-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinecarbaldehyde
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carbaldehyde
1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyriMidine-5-carbaldehyde | [Molecular Formula]
C10H12N2O6 | [MOL File]
4494-26-2.mol | [Molecular Weight]
256.21 |
| Chemical Properties | Back Directory | [Melting point ]
162 - 164°C | [density ]
1.670±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly, Sonicated) | [form ]
Solid | [pka]
8.23±0.10(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein[1]. | [References]
[1] Sugiyama T, et al. Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2′-deoxyuridine[J]. Nucleosides, Nucleotides and Nucleic Acids, 2001, 20(4-7): 1079-1083. DOI:10.1081/NCN-100002494 |
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