| Identification | Back Directory | [Name]
1-(1H-INDAZOL-3-YL)ETHANONE | [CAS]
4498-72-0 | [Synonyms]
3-ACETYLINDAZOLE
3-Acetyl-1H-indazole
3-Acetylindazole(WX626026)
1-(indazol-3-yl)ethan-1-one
1-(1H-INDAZOL-3-YL)ETHANONE
1-(1H-Indazole-3-yl)ethanone
Ethanone, 1-(1H-indazol-3-yl)-
1-(1H-indazol-3-yl)ethan-1-one
Ethanone, 1-(1H-indazol-3-yl)- (9CI) | [Molecular Formula]
C9H8N2O | [MDL Number]
MFCD08234921 | [MOL File]
4498-72-0.mol | [Molecular Weight]
160.17 |
| Chemical Properties | Back Directory | [Melting point ]
182 °C | [Boiling point ]
348.8±15.0 °C(Predicted) | [density ]
1.264±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
11.87±0.40(Predicted) | [Appearance]
Off-white to light yellow Solid |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Synthesis, p. 937, 1992 DOI: 10.1055/s-1992-26268 | [Synthesis]
GENERAL STEPS: To an anhydrous THF solution of N-methoxy-N-methyl-1H-indazole-3-carboxamide (950 mg, 4.63 mmol, 1.1 eq.), the mixture was cooled to 0 °C. Methylmagnesium bromide (7.7 mL, 23.17 mmol, 5.0 eq.) was slowly added dropwise at 0 °C. After the dropwise addition, the reaction mixture was stirred at room temperature for 12 hours. Upon completion of the reaction, the reaction was quenched by the addition of NH4Cl solution (5 mL). Subsequently, the solvent was removed by distillation under reduced pressure and the obtained residue was purified by column chromatography (eluent: ethyl acetate/petroleum ether = 1/2) to afford 1-(1H-indazol-3-yl)ethanone (610 mg, 82.3% yield) as a yellow solid. | [References]
[1] Tetrahedron, 2007, vol. 63, # 2, p. 419 - 428
[2] Patent: WO2018/15818, 2018, A2. Location in patent: Paragraph 00237
[3] Patent: WO2018/64135, 2018, A1. Location in patent: Paragraph 0275-0278
[4] Patent: US2011/65700, 2011, A1. Location in patent: Page/Page column 17
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 10, p. 5138 - 5145 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
ZEROSCHEM.CO.,LTD.
|
| Telephone: |
10-61256048 13810278579; |
| Website: |
http://www.zeroschem.com |
| Company Name: |
Heterochem
|
| Telephone: |
027-88041443 13072715837 |
| Website: |
www.hetero-chem.com |
| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Cool Pharm, Ltd
|
| Telephone: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
|