| Identification | Back Directory | [Name]
4-FLUORO-2-METHOXYANILINE | [CAS]
450-91-9 | [Synonyms]
4-Fluoro-o-anisidine
o-Anisidine, 4-fluoro-
2-Amino-5-fluoroanisole
2-Methoxy-4-fluoroaniline
4-FLUORO-2-METHOXYANILINE
4-Fluoro-2-MethoxybenzenaMine
4-Fluoro-2-methoxyaniline 97%
4-Fluoro-2-methoxyaniline,95%
4-Fluoro-2-methoxy-phenylamine
Benzenamine, 4-fluoro-2-methoxy-
4-Fluoro-o-anisidine, 2-Amino-5-fluoroanisole
2-AMino-5-fluoroanisole[4-Fluoro-2-Methoxyaniline] | [EINECS(EC#)]
814-457-6 | [Molecular Formula]
C7H8FNO | [MDL Number]
MFCD00077536 | [MOL File]
450-91-9.mol | [Molecular Weight]
141.15 |
| Chemical Properties | Back Directory | [Boiling point ]
215℃ (756 Torr) | [density ]
1.176±0.06 g/cm3 (20 ºC 760 Torr) | [refractive index ]
1.5400 to 1.5440 | [Fp ]
79.5±21.8℃ | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Solid | [pka]
4.60±0.10(Predicted) | [color ]
Colorless to Brown | [InChI]
InChI=1S/C7H8FNO/c1-10-7-4-5(8)2-3-6(7)9/h2-4H,9H2,1H3 | [InChIKey]
BNRRMRUVYDETQC-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(F)C=C1OC |
| Hazard Information | Back Directory | [Uses]
4-?Fluoro-?2-?methoxyaniline is a useful synthetic intermediate. It is used to prepare ortho-?substituted phenylureas as 5-?Hydroxytryptamine (5-?HT3) receptor antagonists. It is also used to synthesize hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain. | [Application]
4-Fluoro-2-methoxyaniline is a useful synthetic intermediate. It is used to prepare ortho-substituted phenylureas as 5-Hydroxytryptamine (5-HT3) receptor antagonists. It is also used to synthesize hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain. | [Synthesis]
Using 4-fluoro-2-o-methoxynitrobenzene as the starting material, the target compound 4-fluoro-2-methoxyaniline was prepared by hydrogenation reduction reaction.
 | [References]
[1] Patent: US6352993, 2002, B1. Location in patent: Page column 30
[2] Patent: CN106366072, 2017, A. Location in patent: Paragraph 0062; 0063; 0064; 0090; 0091; 0092
[3] Patent: CN106366022, 2017, A. Location in patent: Paragraph 0051; 0052; 0056
[4] Patent: US2011/130415, 2011, A1. Location in patent: Page/Page column 102
[5] Patent: WO2018/207120, 2018, A1. Location in patent: Page/Page column 11; 12 |
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| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
skychemical Co.Ltd
|
| Telephone: |
021-20958197 20965099 |
| Website: |
www.skychemical.com |
|