| Identification | Back Directory | [Name]
L-Glutamic acid α-tert·butyl ester | [CAS]
45120-30-7 | [Synonyms]
L-Glu-OtBu
α-tert-Butyl L-GlutaMate
L-Glutamicacida-tertutylester
L-Glutamic acid α-tert·butyl ester
1-TERT-BUTYL L-GLUTAMATE,98.0+%(T)
L-Glutamic Acid 1-tert-Butyl Ester
t-butoxycarbonyl-γ-aMinobutyric acid
L-GLUTAMIC ACID ALPHA-TERTBUTYL ESTER
L-Glutamic acid 1-(1,1-dimethylethyl) ester
(S)-4-amino-5-tert-butoxy-5-oxopentanoic acid
L-Glutamic acid α-tert-butyl ester≥ 98% (HPLC)
(4S)-4-AMino-5-[(2-Methyl-2-propanyl)oxy]-5-oxopentanoic acid (non-preferred naMe) | [Molecular Formula]
C9H17NO4 | [MDL Number]
MFCD00038562 | [MOL File]
45120-30-7.mol | [Molecular Weight]
203.24 |
| Questions And Answer | Back Directory | [Synthesis]
Add 581g of tert-butyl acetate and 147g of glutamic acid to a 2000mL three-necked flask, stir, add 100mL of perchloric acid dropwise, react at 20℃ for 48 hours, cool to 0℃, add 600mL of water, neutralize with Na2CO3 to pH=8-9, separate the phases, wash three times with 100mL of 1% Na2CO3 aqueous solution, combine the aqueous phases, and extract three times with 200mL of petroleum ether to obtain crude product containing L-Glutamic acid α-tert-butyl ester. 
| [Purity]
99% |
| Chemical Properties | Back Directory | [Melting point ]
140 °C | [Boiling point ]
326.8±32.0 °C(Predicted) | [density ]
1.133±0.06 g/cm3(Predicted) | [refractive index ]
14 ° (C=1, H2O) | [storage temp. ]
Store at 0°C | [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Sparingly, Sonicated) | [form ]
Powder | [pka]
4.22±0.10(Predicted) | [color ]
White | [InChI]
InChI=1S/C9H17NO4/c1-9(2,3)14-8(13)6(10)4-5-7(11)12/h6H,4-5,10H2,1-3H3,(H,11,12)/t6-/m0/s1 | [InChIKey]
QVAQMUAKTNUNLN-LURJTMIESA-N | [SMILES]
C(OC(C)(C)C)(=O)[C@H](CCC(O)=O)N | [CAS DataBase Reference]
45120-30-7 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
L-Glutamic Acid α-tert-Butyl Ester is an ester of L-Glutamic Acid used in the synthesis of enantiopure isotopomers of amino acids. | [Description]
L-Glutamic acid α-tert-butyl ester (CAS 45120-30-7) is a high-purity, asymmetrically protected amino acid building block. Its synonyms include: H-Glu-OtBu, L-Glu-OtBu, Glu-OtBu, 1-tert-butyl L-glutamate and glutamic acid tert-butyl ester, amongst others. The α-position of this molecule contains a carboxyl group protected by a tert-butyl ester, whilst the carboxyl group at the other end is free and can be used to attach side chains for the preparation of long-acting GLP-1 analogues or for PROTAC synthesis. Please note the distinction in structure from L-Glutamic acid γ-tert-butyl ester (CAS 2419-56-9). |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956 |
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https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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