ChemicalBook--->CAS DataBase List--->452072-20-7

452072-20-7

Request For Quotation
452072-20-7 Structure

452072-20-7 Structure
IdentificationBack Directory
[Name]

DM1-SPP
[CAS]

452072-20-7
[Synonyms]

DM1-SPP
SPP-DM1
Maytansine, N2'-deacetyl-N2'-[3-[[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-4-oxobutyl]dithio]-1-oxopropyl]-
[Molecular Formula]

C44H59ClN4O14S2
[MDL Number]

MFCD28400101
[MOL File]

452072-20-7.mol
[Molecular Weight]

967.54
Chemical PropertiesBack Directory
[density ]

1.39±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

9.82±0.70(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

SPP-DM1 is a agent-linker conjugate for ADC with potent antitumor activity by using DM1 (a potent microtubule-disrupting agent), linked via the ADC linker SPP[1].
[IC 50]

Maytansinoids
[References]

[1] Manu Lopus et al. Maytansine and Cellular Metabolites of Antibody-Maytansinoid Conjugates Strongly Suppress Microtubule Dynamics by Binding to Microtubules. DOI:10.1158/1535-7163.MCT-10-0644
452072-20-7 suppliers list
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: https://www.bocsci.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Website: www.bio-fount.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Website: www.zzsrm.com
Company Name: Guangzhou Junze Biotechnology Co., Ltd.  
Tel: 17688489295
Website: www.chemicalbook.com/ShowSupplierProductsList1792761/0_EN.htm
Tags:452072-20-7 Related Product Information