| Identification | Back Directory | [Name]
H-LYS-GLU-OH | [CAS]
45234-02-4 | [Synonyms]
Vilon
Lys-Glu-OH
L-LYS-L-GLU
H-LYS-GLU-OH
Vilon acetate
Vilon peptide
L-Lys-L-Glu-OH
L-LysyI-L-glutamate
H-GLU-EPSILON-LYS-OH
H-LYS-GLU-OH USP/EP/BP
L-LYSYL-L-GLUTAMIC ACID
N-L-Lysyl-L-glutamic acid
L-Glutamic acid, L-lysyl-
N-L-Lysyl-L-glutamic acid≥ 99% (TLC)
(S)-2-((S)-2,6-Diaminohexanamido)pentanedioic acid
(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]pentanedioic acid | [EINECS(EC#)]
-0 | [Molecular Formula]
C11H21N3O5 | [MDL Number]
MFCD00038215 | [MOL File]
45234-02-4.mol | [Molecular Weight]
275.3 |
| Chemical Properties | Back Directory | [Melting point ]
195-197 °C | [Boiling point ]
596.4±50.0 °C(Predicted) | [density ]
1.290±0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [form ]
solid | [pka]
3.00±0.10(Predicted) | [InChI]
InChI=1S/C11H21N3O5/c12-6-2-1-3-7(13)10(17)14-8(11(18)19)4-5-9(15)16/h7-8H,1-6,12-13H2,(H,14,17)(H,15,16)(H,18,19)/t7-,8-/m0/s1 | [InChIKey]
UGTZHPSKYRIGRJ-YUMQZZPRSA-N | [SMILES]
C(O)(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)N |
| Hazard Information | Back Directory | [Description]
H-LYS-GLU-OH (also known as lysylglutamic acid) is a basic dipeptide containing two amino groups and two carboxyl groups. Studies have shown that this compound exerts a significant immunomodulatory effect on both young and aged rat spleen cell cultures, stimulating the proliferation of undifferentiated T lymphocytes (CD5⁺) and B lymphocytes (CD20⁺) [2]. Furthermore, this dipeptide can serve as a starting material for the preparation of various derivatives, including diketopiperazine derivatives and ε-guanidino derivatives [3]. | [Chemical Properties]
White powder | [Uses]
Lysylglutamic acid is a dipeptide formed by combining two amino acids, Lysine (Lys) and Glutamic acid (Glu). The Ki value of the membrane transporter PEPT1 was 1.3 mM[1]. | [Definition]
ChEBI: A dipeptide formed from L-lysine and L-glutamic acid residues. | [References]
[1] Biegel A, et al. Three-dimensional quantitative structure-activity relationship analyses of beta-lactam antibiotics and tripeptides as substrates of the mammalian H+/peptide cotransporter PEPT1. J Med Chem. 2005 Jun 30;48(13):4410-9. DOI:10.1021/jm048982w
[2] Кузнецова Е.П., Костылев А.В., Червякова Н.А. (2013). Пептиды восстанавливают иммуногенез в селезенке при ее старении. Российский семейный врач, 17 (3), 33-36. https://cyberleninka.ru/article/n/peptidy-vosstanavlivayut-immunogenez-v-selezenke-pri-ee-starenii
[3] Greenstein, J. (1900). STUDIES OF MULTIVALENT AMINO ACIDS AND PEPTIDES. 0. https://doi.org/10.1016/s0021-9258(18)75185-5
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